It is well known that there are specific windows of time in early development and throughout life when environmental stressors elevate the risk for later onset disease. Primary stressors during early life include poor nutrient acquisition, toxic social stress, environmental toxic chemicals, low oxygen during prenatal development and poor postnatal maternal nurture. During the developmental processes before birth and in the first few years of life, stresses can lead to abnormal structure of developing organs that are then predisposed to diseases. More importantly, however, stage-specific stresses lead to modification of regulatory regions of DNA, modification of proteins around which DNA is wrapped and modification of non-coding RNA species. The sum effect of these epigenetic processes can predispose people to pathological conditions and chronic disease that can be passed to the next generation of offspring through the germ line. These harmful epigenetic processes are, unlike purely genetic drivers, potentially reversible. Potential reversibility offers people who are vulnerable for acquiring chronic diseases a way to take advantage of lifestyle choices that reduce the propensity for adult-onset disease.


The date


Tue, 23 Oct 2018


2:00pm - 3:15pm